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It has been reported that the generation of EVs in erythrocytes occurs in response to oxidative stress, Ca 2+ overload, and the PS externalization-associated phospholipid membrane asymmetry [237]

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Pre-clinical studies done on C57BL/6J mice using total body irradiation (9 Gy) found that radiation reduced -diversity of gut microbiota, while urolithin A (UroA), a gut microbial metabolite, helps in alleviating radiation-induced apoptosis in intestinal cells by suppressing P53 signaling pathway (Zhang et al., 2021c